"Calendar Year (CY) 2022 Clinical Laboratory Fee Schedule (CLFS) Final Payment Determinations1

This first worksheet A. Final Determinations of this Excel workbook contains all of the new CLFS codes and CMS final payment determinations. The second worksheet ""B. Edits or Corrections"" contains any edits/corrections to the original CMS final payment determinations Excel workbook that was displayed on the CMS website on November 24, 2021. 

We welcome reconsideration requests on our final determinations for the basis of payment.  All comments must be submitted electronically by January 24, 2022 to the following CMS mailbox: CLFS_Annual_Public_Meeting@cms.hhs.gov.  When submitting reconsideration requests, please refer to the specific code and its rationale.

1CPT codes, descriptions and other data only are copyright 2021 American Medical Association. All Rights Reserved. Applicable FARS/HHSARS apply. Fee schedules, relative value units, conversion factors and/or related components are not assigned by the AMA, are not part of CPT, and the AMA is not recommending their use. The AMA does not directly or indirectly practice medicine or dispense medical services. The AMA assumes no liability for data contained or not contained herein."													
FACA Panel Item #	ALM Item #	Code Type	Category	Code #	Final Code #	Long Code Descriptor	"CDLT Panel Voting Results
"	CMS 2021 Preliminary Recommendation	Rationale	CMS 2021 Final Determination	Rationale		
1	7	NEW	Proprietary Laboratory Analyses/ Immunology	0226U	0226U	"Surrogate viral neutralization test (sVNT), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), ELISA, plasma, serum
"	1. Crosswalk to: 86769: 12	Gapfill	CMS disagrees with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
2	8	NEW	Immunology / Immunology	86413	86413	"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) antibody,quantitative"	"1. Crosswalk to: 86769 x 1.25: 3
2. Crosswalk to 86769 x 2: 8
3. Abstain: 1"	Gapfill	CMS disagrees with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	"Finalize as proposed. After reviewing public comments, CMS continues to believe gapfilling this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC) as the public health emergency continues."		
3	63	NEW	Immunology / Immunology	863X4	86381	"Mitochondrial antibody (eg, M2), each"	1. Crosswalk to 86146: 12	Crosswalk to 86146	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86146	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
4	64	NEW	Immunology / Immunology	865X0	86596	"Voltage-gated calcium channel antibody, each"	1. Crosswalk to 84586: 12	Crosswalk to 83519	"CMS disagrees with the Panel Recommendation and instead is recommending a different crosswalk.  Currently a VGCC antibody panel is billed using 83519x2 and looks at 2 antibodies.  Therefore, CMS recommends that for each VGCC antibody, the crosswalk should be to 83519x1."	Crosswalk to 83519	"Finalize as proposed. After reviewing public comments, CMS continues to believe a crosswalk to CPT 83519 is appropriate.  CMS believes the methods are similar between the two codes. "		
5	65	NEW	Immunology / Immunology	86XX0	86015	"Actin (smooth muscle) antibody (ASMA), each"	"1. Crosswalk to 86146: 2
2. Crosswalk to 83516: 10"	Crosswalk to 83516	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83516	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 83516.  We believe there are similar methods between the two codes. 		
6	66	NEW	Immunology / Immunology	86X00	86036	"Antineutrophil cytoplasmic antibody (ANCA); screen, each antibody"	"1. Crosswalk to 86146: 2
2. Crosswalk to 86255: 10"	Crosswalk to 86255	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86255	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 86255.  We believe there are similar methods between the two codes. 		
7	67	NEW	Immunology / Immunology	86X01	86037	"Antineutrophil cytoplasmic antibody (ANCA); titer, each antibody"	1. Crosswalk to 86256: 12	Crosswalk to 86256	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86256	Finalize as proposed.  After reviewing public comments CMS continues to recommend a crosswalk to CPT 86256.  We believe there are similar methods between the two codes. 		
8	79	NEW	Proprietary Laboratory Analyses: Immunology/ Immunology	0X65U	0275U	"Hematology (heparin-induced thrombocytopenia) platelet antibody reactivity by flow cytometry, serum"	1. Gapfill: 12	Crosswalk to 86022	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86022	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
9	80	NEW	Proprietary Laboratory Analyses: Immunology/ Immunology	0X66U	0280U	"Hematology (von Willebrand disease [VWD]), von Willebrand factor (VWF) and collagen IV binding by enzyme-linked immunosorbent assays (ELISA), plasma, report of collagen IV binding"	"1. Crosswalk to 83520: 11
2. Abstain: 1"	Crosswalk to 83520	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83520	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
10	81	NEW	Proprietary Laboratory Analyses: Immunology/ Immunology	0X67U	0281U	"Hematology (von Willebrand disease [VWD]), von Willebrand propeptide, enzyme-linked immunosorbent assays (ELISA), plasma, diagnostic report of von Willebrand factor (VWF) propeptide antigen level"	"1. Crosswalk to 83520: 6
2. Crosswalk to 85246: 5
3. Abstain: 1"	Crosswalk to 83520	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83520	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
11	82	NEW	Proprietary Laboratory Analyses: Immunology/ Immunology	0X68U	0283U	"von Willebrand factor (VWF), type 2B, platelet-binding evaluation, radioimmunoassay, plasma"	"1. Crosswalk to 83519: 11
2. Abstain: 1"	Crosswalk to 83519	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83519	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
12	83	NEW	Proprietary Laboratory Analyses: Immunology/ Immunology	0X69U	0284U	"von Willebrand factor (VWD), type 2N, factor VIII and VWF binding evaluation, enzyme-linked immunosorbent assays (ELISA), plasma"	"1. Crosswalk to 83520: 1
2. Crosswalk to 85246 x 1.5: 4
3. Crosswalk to 85246 x 2: 6"	Crosswalk to 83520	CMS agrees with the minority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83520	Finalize as proposed. CMS agrees with the minority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
13	40	NEW	Immunology / Immunology	860XX	86051	Aquaporin-4 (neuromyelitis optica [NMO]) antibody; enzyme-linked immunosorbent immunoassay (ELISA)	"1. Crosswalk to 86146: 11
2. Abstain: 1"	Crosswalk to 83516	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83516	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 83516.  We believe there are similar methods between the two codes. 		
14	41	NEW	Immunology / Immunology	860X1	86052	"Aquaporin-4 (neuromyelitis optica [NMO]) antibody; cell-based immunofluorescence assay (CBA), each"	"1. Crosswalk to 86341: 11
2. Abstain: 1"	Crosswalk to 86255	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86255	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 86255.  We believe there are similar methods between the two codes. 		
15	42	NEW	Immunology / Immunology	860X2	86053	"Aquaporin-4 (neuromyelitis optica [NMO]) antibody; flow cytometry (ie, fluorescence-activated cell sorting [FACS]), each"	"1. Crosswalk to 86367: 11
2. Abstain: 1"	Crosswalk to 86255	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86255	Finalize as proposed.  After reviewing public comments CMS continues to recommend a crosswalk to CPT 86255.  We believe there are similar methods between the two codes. 		
16	43	NEW	Immunology / Immunology	863X2 	86362	"Myelin oligodendrocyte glycoprotein (MOG-IgG1) antibody; cell-based immunofluorescence assay (CBA), each"	"1. Crosswalk to 86357: 11
2. Abstain: 1"	Crosswalk to 86255	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86255	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 86255.  We believe there are similar methods between the two codes. 		
17	44	NEW	Immunology / Immunology	863X3	86363	"Myelin oligodendrocyte glycoprotein (MOG-IgG1) antibody; flow cytometry (ie, fluorescence-activated cell sorting [FACS]), each"	"1. Crosswalk to 86367: 11
2. Abstain: 1"	Crosswalk to 86255	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86255	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 86255.  We believe there are similar methods between the two codes. 		
18	45	NEW	Immunology / Immunology	862X0	86231	"Endomysial antibody (EMA), each immunoglobulin (Ig) class"	"1. Crosswalk to 86038: 5
2. Crosswalk to 86038 x 2: 6
3. Abstain: 1"	Crosswalk to 86038	CMS agrees with the minority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 86038	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 86038.  We believe there are similar methods between the two codes. 		
19	46	NEW	Immunology / Immunology	862XX	86258	"Gliadin (deamidated) (DGP) antibody, each immunoglobulin (Ig) class"	"1. Crosswalk to 86147: 11
2. Abstain: 1"	Crosswalk to 83516	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83516	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 83516.  We believe there are similar methods between the two codes. 		
20	47	NEW	Immunology / Immunology	862X1	86364	"Tissue transglutaminase, each immunoglobulin (Ig) class"	"1. Crosswalk to 86147: 11
2. Abstain: 1"	Crosswalk to 83516	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83516	Finalize as proposed. After reviewing public comments CMS continues to recommend a crosswalk to CPT 83516.  We believe there are similar methods between the two codes. 		
21	98	NEW	Proprietary Laboratory Analyses: Immunology/ Immunology	0X85U	0279U	"Hematology (von Willebrand disease [VWD]), von Willebrand factor (VWF) and collagen III binding by enzyme-linked immunosorbent assays (ELISA), plasma, report of collagen III binding"	"1. Crosswalk to 83520: 4
2. Crosswalk to 85246: 7
3. Abstain: 1"	Crosswalk to 83516	CMS disagrees with the Panel Recommendation and instead is recommending a  crosswalk. The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 83516	Finalize as proposed.  CMS continues to disagrees with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
22	4	NEW	Immunology / Immunology	86408	86408	"Neutralizing antibody, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]); screen"	"1. Crosswalk to 86769: 1
2. Gapfill: 11"	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	"Finalize as proposed. After reviewing public comments, CMS continues to believe gapfilling this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC)as the public health emergency continues."		
23	5	NEW	Immunology / Immunology	86409	86409	"Neutralizing antibody, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]); titer"	1. Gapfill: 12	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	"Finalize as proposed. After reviewing public comments, CMS continues to believe gapfilling this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC)as the public health emergency continues."		
24	1	NEW	Microbiology: Immunoassay/  Microbiology	87426	87426	"Infectious agent antigen detection by immunoassay technique, (eg, enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], immunochemiluminometric assay [IMCA]) qualitative or semiquantitative, multiple-step method; severe acute respiratory syndrome coronavirus (eg, SARS-CoV, SARS-CoV-2 [COVID-19])

"	"1. Crosswalk to 87430 x 2.5: 1
2. Crosswalk to 87430 x 2: 11"	Gapfill	CMS disagrees with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	"Finalize as proposed. After reviewing public comments, CMS continues to believe gapfilling this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC)as the public health emergency continues."		
25	2	NEW	Proprietary Laboratory Analyses:  Microbiology/  Microbiology	0223U	0223U	"Infectious disease (bacterial or viral respiratory tract infection), pathogen-specific nucleic acid (DNA or RNA), 22 targets including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), qualitative RT-PCR, nasopharyngeal swab, each pathogen reported as detected or not detected"	1. Crosswalk to 87633: 12	Crosswalk to 87633	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 87633	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
26	3	NEW	Proprietary Laboratory Analyses:  Microbiology/  Microbiology	0224U	0224U	"Antibody, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), includes titer(s), when performed"	"1. Crosswalk to 86769: 11
2. Abstain: 1"	Gapfill	CMS disagrees with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
27	9	NEW	Proprietary Laboratory Analyses:  Microbiology/  Microbiology	0240U	0240U	"Infectious disease (viral respiratory tract infection), pathogen-specific RNA, 3 targets (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], influenza A, influenza B), upper respiratory specimen, each pathogen reported as detected or not detected
"	"1. Crosswalk to 87631: 11
2. Abstain: 1"	Crosswalk to 87631	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 87631	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
28	10	NEW	Proprietary Laboratory Analyses:  Microbiology/  Microbiology	0241U	0241U	"Infectious disease (viral respiratory tract infection), pathogen-specific RNA, 4 targets (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], influenza A, influenza B, respiratory syncytial virus [RSV]), upper respiratory specimen, each pathogen reported as detected or not detected"	"1. Crosswalk to 87631: 11
2. Abstain: 1"	Crosswalk to 87631	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 87631	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
29	57	NEW	Microbiology/ Microbiology	87636	87636	"Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]) and influenza virus types A and B, multiplex amplified probe technique"	"1. Crosswalk to 87631: 11
2. Abstain: 1"	Crosswalk to 87631	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 87631	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
30	58	NEW	Microbiology/ Microbiology	87637	87637	"Infectious agent detection by nucleic acid (DNA or RNA); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Coronavirus disease [COVID-19]), influenza virus types A and B, and respiratory syncytial virus, multiplex amplified probe technique"	"1. Crosswalk to 87631: 11
2. Abstain: 1"	Crosswalk to 87631	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 87631	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
31	60	NEW	Microbiology/ Microbiology	87811	87811	"Infectious agent antigen detection by immunoassay with direct optical (ie, visual) observation; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 
(Coronavirus disease [COVID-19])
"	"1. Crosswalk to 87804 x 2.5: 1
2. Crosswalk to 87804 x 2: 11"	Gapfill	CMS disagrees with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	"After reviewing public comments, CMS continues to believe gapfilling this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC)as the public health emergency continues."		
32	68	NEW	Microbiology/ Microbiology	8715X	87154	"Culture, typing; identification of blood pathogen and resistance typing, when performed, by nucleic acid (DNA or RNA) probe, multiplexed amplified probe technique including multiplex reverse transcription, when performed, per culture or isolate, 6 or more targets"	"1. Crosswalk to 87506: 11
2. Gapfill: 1"	Crosswalk to 87632	"CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  Instead, CMS recommends a different crosswalk that appears to use similar methods and resource utilization."	Crosswalk to 87632	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
33	59	NEW	Microbiology/ Microbiology	87428	87428	"Infectious agent antigen detection by immunoassay technique, (eg, enzyme immunoassay  [EIA], enzyme-linked immunosorbent assay [ELISA], fluorescence immunoassay [FIA], immunochemiluminometric assay [IMCA]) qualitative or semiquantitative; severe acute respiratory syndrome coronavirus (eg, SARS-CoV, SARS-CoV-2 [COVID-19]) and influenza virus types A and B
"	"1. Crosswalk to 87430 x2.5 + 87400 x 2: 2
2. Crosswalk to 87430 x 2 + 87400 x 2: 10"	Crosswalk to 87400+87449	"CMS agrees with the recommended crosswalk codes for this test, but disagrees with the use of multipliers.  "	Crosswalk to 87430+87400	"After additional review and further consideration, CMS agrees with the majority recommendation of the CDLT Panel to crosswalk this code, but without the use of the multipliers.  The crosswalked code(s) appear to use similar methods and resource utilization."		
34	11	NEW	"Proprietary Laboratory Analyses  Chemistry / Drug Testing, Metabolism and Therapeutic monitoring"	0227U	0227U	"Drug assay, presumptive, 30 or more drugs or metabolites, urine, liquid chromatography with tandem mass spectrometry (LC-MS/MS) using multiple reaction monitoring (MRM), with drug or metabolite description, includes sample validation"	1. Crosswalk to 80307: 12	Crosswalk to 80307	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 80307	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
35	53	Reconsidered	Other Methods of Sequencing: Common variants   / Other Methods of Sequencing/ Reconsidered	81338	81338	"MPL (MPL proto-oncogene, thrombopoietin receptor) (eg, myeloproliferative disorder) gene analysis; common variants (eg, W515A, W515K, W515L, W515R)"	1. Crosswalk to 81120: 12	Crosswalk to 81402	"CMS disagrees with the recommendation of the CDLT Panel and commenters to crosswalk molecular pathology tests to different gene analysis tests.  In the most recent years, CMS utilized codes known as Tier 2 molecular pathology test codes as crosswalks for these types of tests.  Tier 2 molecular pathology test codes are based on ranges of genetic analysis (i.e. 2-5 exons, 3-5 genes).  We finalized this crosswalking approach for the past three years as we believe it to be a more transparent and consistent method."	Crosswalk to 81402	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
36	54	Reconsidered	Other Methods of Sequencing:  Targeted sequence analysis   / Other Methods of Sequencing / Reconsidered	81339	81339	"MPL (MPL proto-oncogene, thrombopoietin receptor) (eg, myeloproliferative disorder) gene analysis; sequence analysis, exon 10"	1. Crosswalk to 81310: 12	Crosswalk to 81403	"CMS disagrees with the recommendation of the CDLT Panel and commenters to crosswalk molecular pathology tests to different gene analysis tests.  In the most recent years, CMS utilized codes known as Tier 2 molecular pathology test codes as crosswalks for these types of tests.  Tier 2 molecular pathology test codes are based on ranges of genetic analysis (i.e. 2-5 exons, 3-5 genes).  We finalized this crosswalking approach for the past three years as we believe it to be a more transparent and consistent method."	Crosswalk to 81403	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
37	61	NEW	"Therapeutic Drug Assay / Drug testing, Metabolism and Therapeutic monitoring"	801XX	80220	Hydroxychloroquine	1. Crosswalk to 80204: 12	Crosswalk to 80299	"CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  Instead, CMS recommends a different crosswalk that appears to use similar methods and resource utilization."	Crosswalk to 80299	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
38	32	NEW	"Proprietary Laboratory Analyses  Oncology therapeutic response / Drug Testing, Metabolism and Therapeutic monitoring"	0248U	0248U	"Oncology (brain), spheroid cell culture in a 3D microenvironment, 12 drug panel, tumor-response prediction for each drug"	1. Gapfill: 12	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
39	48	Reconsidered	"Chemistry: Drug Testing, Monitoring / Drug Testing, Metabolism and Therapeutic monitoring / Reconsidered"	80151	80151	Amiodarone	1. Crosswalk to 80155: 12	Crosswalk to 80299	CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  CMS continues to believe the original crosswalk recommendation is appropriate for this test. 	Crosswalk to 80299	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
40	49	Reconsidered	"Chemistry: Drug Testing, Monitoring / Drug Testing, Metabolism and Therapeutic monitoring / Reconsidered"	80161	80161	"Carbamazepine; 10,11-epoxide"	1. Crosswalk to 80155: 12	Crosswalk to 80299	CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  CMS continues to believe the original crosswalk recommendation is appropriate for this test. 	Crosswalk to 80299	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
41	50	Reconsidered	"Chemistry: Drug Testing, Monitoring / Drug Testing, Metabolism and Therapeutic monitoring / Reconsidered"	80167	80167	Felbamate	1. Crosswalk to 80199: 12	Crosswalk to 80299	CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  CMS continues to believe the original crosswalk recommendation is appropriate for this test. 	Crosswalk to 80299	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
42	51	Reconsidered	"Chemistry: Drug Testing, Monitoring / Drug Testing, Metabolism and Therapeutic monitoring / Reconsidered"	80181	80181	Flecainide	"1. Crosswalk to 80193: 2
2. Crosswalk to 80155: 10"	Crosswalk to 80299	CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  CMS continues to believe the original crosswalk recommendation is appropriate for this test. 	Crosswalk to 80299	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
43	52	Reconsidered	Other Methods of Sequencing:  Targeted sequence analysis   / Other Methods of Sequencing/ Reconsidered	81279	81279	"JAK2 (Janus kinase 2) (eg, myeloproliferative disorder) targeted sequence analysis (eg, exons 12 and 13)"	"1. Crosswalk to 81272: 11
2. Crosswalk to 81403: 1"	Crosswalk to 81403	CMS  disagrees with the majority CDLT Panel recommended crosswalk for this code.  CMS continues to believe the original crosswalk recommendation is appropriate for this test. 	Crosswalk to 81403	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
44	6	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0225U	0225U	"Infectious disease (bacterial or viral respiratory tract infection) pathogen-specific DNA and RNA, 21 targets, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), amplified probe technique, including multiplex reverse transcription for RNA targets, each analyte reported as detected or not detected"	1. Crosswalk to 87633: 12	Crosswalk to 87633	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 87633	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
45	12	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0228U	0228U	"Oncology (prostate), multianalyte molecular profile by photometric detection of macromolecules adsorbed on nanosponge array slides with machine learning, utilizing first morning voided urine, algorithm reported as likelihood of prostate cancer"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
46	55	NEW	Multi-Analyte Assay with Algorithmic Analyses:  Transplantation / Tests with algorithm in code descriptor to report risk/likelihood/predictive score 	815X0 	81560	"Transplantation medicine (allograft rejection, pediatric liver and small bowel), measurement of donor and third-party-induced CD154+T-cytotoxic memory cells, utilizing whole peripheral blood, algorithm reported as a rejection risk score"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
47	56	NEW	Multi-Analyte Assay with Algorithmic Analyses:  Oncology breast / Tests with algorithm in code descriptor to report risk/likelihood/predictive score 	815X1 	81523	"Oncology (breast), mRNA, next-generation sequencing gene expression profiling of 70 content genes and 31 housekeeping genes, utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as index related to risk to distant metastasis "	1. Crosswalk to 81521: 11	Crosswalk to 81521	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 81521	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
48	25	NEW	Multi-Analyte Assay with Algorithmic Analyses:  Oncology lymphoma/ Tests with algorithm in code descriptor to report risk/likelihood/predictive score 	0017M	0017M	"Oncology (diffuse large B-cell lymphoma [DLBCL]), mRNA, gene expression profiling by fluorescent probe hybridization of 20 genes, formalin-fixed paraffin-embedded tissue, algorithm reported as cell of origin"	1. Crosswalk to 0120U: 11	Crosswlk to 0120U	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswlk to 0120U	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
49	26	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0243U	0243U	"Obstetrics (preeclampsia), biochemical assay of placental-growth factor, time-resolved fluorescence immunoassay, maternal serum, predictive algorithm reported as a risk score for preeclampsia"	1. Crosswalk to 82731: 11	Crosswalk to 82731	CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.	Crosswalk to 82731	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
50	69	NEW	Multi-Analyte Assay with Algorithmic Analyses / Tests with algorithm in code descriptor to report risk/likelihood/predictive score 	002XM	0018M	"Transplantation medicine (allograft rejection, renal), measurement of donor and third-party-induced CD154+T-cytotoxic memory cells, utilizing whole peripheral blood, algorithm reported as a rejection risk score"	1. Gapfill: 11 	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
51	70	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0X56U	0255U	"Andrology (infertility), sperm-capacitation assessment of ganglioside GM1 distribution patterns, fluorescence microscopy, fresh or frozen specimen, reported as percentage of capacitated sperm and probability of generating a pregnancy score"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
52	73	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0X59U	0258U	"Autoimmune (psoriasis), mRNA, next-generation sequencing, gene expression profiling of 50-100 genes, skin- surface collection using adhesive patch, algorithm reported as likelihood of response to psoriasis biologics"	"1. Crosswalk to 0019U: 6
2. Gapfill: 5"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Crosswalk to 0019U	"After additional review and further consideration, CMS agrees with the majority recommendation of the CDLT Panel to crosswalk this code.  The crosswalked code(s) appear to use similar methods and resource utilization."		
53	28	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0245U	0245U	"Oncology (thyroid), mutation analysis of 10 genes and 37 RNA fusions and expression of 4 mRNA markers using next-generation sequencing, fine needle aspirate, report includes associated risk of malignancy expressed as a percentage"	"1. Crosswalk to 81455: 9
2. Gapfill: 2"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	After reviewing public comments CMS still feels gapfill is the most appropriate.  This will allow the MACs to review the code more closely and particularly look at other codes similar. 		
54	30	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0247U	0247U	"Obstetrics (preterm birth), insulin-like growth factorbinding protein 4 (IBP4), sex hormone binding globulin (SHBG), quantitative measurement by LC-MS/MS, utilizing maternal serum, combined with clinical data, reported as predictive-risk stratification for spontaneous preterm birth"	"1. Crosswalk to 0080U X 0.2: 10
2. Gapfill: 1"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Crosswalk to 0063U	"After additional review and further consideration, CMS is finalizing a crosswalk to 0063U.  The crosswalked code(s) appear to use similar methods and resource utilization."		
55	31	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0252U	0252U	"Fetal aneuploidy short tandemrepeat comparative analysis, fetal DNA from products of conception, reported as normal (euploidy), monosomy, trisomy, or partial deletion/duplications, mosaicism, and segmental aneuploidy"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
56	33	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0249U	0249U	"Oncology (breast), semiquantitative analysis of 32 phosphoproteins and protein analytes, includes laser capture microdissection, with algorithmic analysis and interpretative report"	"1. Crosswalk to 0037U: 2
2. Gapfill: 9"	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
57	36	NEW	Proprietary Laboratory Analyses: Molecular Pathology (Other than GSP or MAAA)	0253U	0253U	"Reproductive medicine (endometrial receptivity analysis), RNA gene expression profile, 238 genes by next-generation sequencing, endometrial tissue, predictive algorithm reported as endometrial window of implantation (eg, pre-receptive, receptive, post-receptive)"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
58	37	NEW	Proprietary Laboratory Analyses: MAAA NGS Reproductive medicine 	0254U	0254U	"Reproductive medicine (preimplantation genetic assessment), analysis of 24 chromosomes using embryonic DNA genomic sequence analysis for aneuploidy, and a mitochondrial DNA score in euploid embryos, results reported as normal (euploidy), monosomy, trisomy, or partial deletion/duplications, mosaicism, and segmental aneuploidy, per embryo tested"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
59	84	NEW	Proprietary Laboratory Analyses: MAAA Oncology 	0X71U	0262U	"Oncology (solid tumor), gene expression profiling by real-time RT-PCR of 7 gene pathways (ER, AR, PI3K, MAPK, HH, TGFB, Notch), formalin-fixed paraffin-embedded (FFPE), algorithm reported as gene pathway activity score"	"1. Crosswalk to 0011M: 8
2. Gapfill: 3"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
60	100	NEW	Proprietary Laboratory Analyses 	0X70U	0261U	"Oncology (colorectal cancer), image analysis with artificial intelligence assessment of 4 histologic and immunohistochemical features (CD3 and CD8 within tumor-stroma border and tumor core), tissue, reported as immune response and recurrence-risk score"	"1. Crosswalk to 0108U: 3
2. Crosswalk to 0108U x 1.2: 4
3. Gapfill: 3
4. Abstain: 1"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Crosswalk to 0108U	"After additional review and further consideration, CMS agrees with the majority recommendation of the CDLT Panel to crosswalk this code.  The crosswalked code(s) appear to use similar methods and resource utilization."		
61	62	NEW	Chemistry	826X0	82653	"Elastase, pancreatic (EL-1), fecal; quantitative"	1. Crosswalk to 82715: 10	Crosswalk to 82715	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 82715	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
62	71	NEW	Proprietary Laboratory Analyses:  Chemistry	0X57U	0256U	"Trimethylamine/trimethylamine N-oxide (TMA/TMAO) profile, tandem mass spectrometry (MS/MS), urine, with algorithmic analysis and interpretive report"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
63	72	NEW	Proprietary Laboratory Analyses:  Chemistry	0X58U	0257U	"Very long chain acyl- coenzyme A (CoA) dehydrogenase (VLCAD), leukocyte enzyme activity, whole blood"	1. Gapfill: 11	Gapfill	CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the majority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
64	74	NEW	Proprietary Laboratory Analyses:  Chemistry	0X60U	0259U	"Nephrology (chronic kidney disease), nuclear magnetic resonance spectroscopy measurement of myo-inositol, valine, and creatinine, algorithmically combined with cystatin C (by immunoassay) and demographic data to determine estimated glomerular filtration rate (GFR), serum, quantitative"	"1. Crosswalk to (83704 x2) + (82610): 2
2. Crosswalk to 83704 + 82610: 6
3. Gapfill: 1"	Crosswalk to 83704 + 82610	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 83704 + 82610	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
65	35	NEW	Proprietary Laboratory Analyses:  Chemistry	0251U	0251U	"Hepcidin-25, enzyme-linked immunosorbent assay (ELISA), serum or plasma"	1. Crosswalk to 83520: 11	Crosswalk to 83520	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 83520	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
66	38	NEW	Chemistry/ Chemistry	"835X1
"	83529	Interleukin-6 (IL-6)	"1. Crosswalk to 83006: 10
2. Abstain: 1"	Crosswalk to 83520	CMS disagrees with the Panel Recommendation and instead is recommending a different crosswalk that is consistent with other similar tests	Crosswalk to 83520	After reviewing public comments CMS continues to recommend a crosswalk to CPT 83520.  We believe there are similar methods between the two codes. 		
67	39	NEW	Chemistry/ Chemistry	8352X	83521	"Immunoglobulin light chains (ie, kappa, lambda), free, each"	1.Crosswalk to 83520: 11	Crosswalk to 83520	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 83520	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
68	90	NEW	Proprietary Laboratory Analyses:  Chemistry / Chemistry 	0X77U	0263U	"Neurology (autism spectrum disorder [ASD]), quantitative measurements of 16 central carbon metabolites (ie, ?-ketoglutarate, alanine, lactate, phenylalanine, pyruvate, succinate, carnitine, citrate, fumarate, hypoxanthine, inosine, malate, S-sulfocysteine, taurine, urate, and xanthine), liquid chromatography tandem mass spectrometry (LC-MS/MS), plasma, algorithmic analysis with result reported as negative or positive (with metabolic subtypes of ASD)"	1. Crosswalk to 0063U: 10	Crosswalk to 0063U	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 0063U	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
69	13	NEW	Proprietary Laboratory Analyses:  Oncology colorectal / Genomic Sequencing Related Tests 	0229U	0229U	"BCAT1 (Branched chain amino acid transaminase 1) or IKZF1 (IKAROS family zinc finger 1) (eg, colorectal cancer) promoter methylation analysis"	1. Crosswalk to 81327 x 2: 9	Crosswalk to 81287	CMS disagrees with the Panel Recommendation and instead is recommending a different crosswalk that is consistent with other similar tests	Crosswalk to 81327	"After reviewing comments CMS agrees that CPT 81327 is the more appropriate crosswalk for 0229U.  However, CMS does not feel a mutliplier of 2 is appropriate, given the CPT descriptor stipulates 1 gene OR the other. "		
70	14	NEW	Proprietary Laboratory Analyses:  Oncology colorectal / Genomic Sequencing Related Tests 	0230U	0230U	"AR (androgen receptor) (eg, spinal and bulbar muscular atrophy, Kennedy disease, X chromosome inactivation), full sequence analysis, including small sequence changes in exonic and intronic regions, deletions, duplications, short tandem repeat (STR) expansions, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81173 + 81204: 9  	Crosswalk to 81173	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81173	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
71	15	NEW	Proprietary Laboratory Analyses:  GSP neuromuscular disorders / Genomic Sequencing Related Tests 	0231U	0231U	"CACNA1A (calcium voltage-gated channel subunit alpha 1A) (eg, spinocerebellar ataxia), full gene analysis, including small sequence changes in exonic and intronic regions, deletions, duplications, short tandem repeat (STR) gene expansions, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81184 + 81185: 9  	Crosswalk to 81185	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81185	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
72	16	NEW	Proprietary Laboratory Analyses:  GSP neuromuscular disorders / Genomic Sequencing Related Tests 	0232U	0232U	"CSTB (cystatin B) (eg, progressive myoclonic epilepsy type 1A, Unverricht-Lundborg disease), full gene analysis, including small sequence changes in exonic and intronic regions, deletions, duplications, short tandem repeat (STR) expansions, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81188 + 81189: 9	Crosswalk to 81189	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81189	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
73	17	NEW	Proprietary Laboratory Analyses:  GSP neuromuscular disorders / Genomic Sequencing Related Tests 	0233U	0233U	"FXN (frataxin) (eg, Friedreich ataxia), gene analysis, including small sequence changes in exonic and intronic regions, deletions, duplications, short tandem repeat (STR) expansions, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81285 + 81286: 9	Crosswalk to 81286	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81286	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
74	18	NEW	Proprietary Laboratory Analyses:  GSP neurodevelopmental disorder / Genomic Sequencing Related Tests 	0234U	0234U	"MECP2 (methyl CpG binding protein 2) (eg, Rett syndrome), full gene analysis, including small sequence changes in exonic and intronic regions, deletions, duplications, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81302 + 81304: 9	Crosswalk to 81302	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81302	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
75	19	NEW	Proprietary Laboratory Analyses:  GSP Inherited disorders / Genomic Sequencing Related Tests 	0235U	0235U	"PTEN (phosphatase and tensin homolog) (eg, Cowden syndrome, PTEN hamartoma tumor syndrome), full gene analysis, including small sequence changes in exonic and intronic regions, deletions, duplications, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81321 + 81323: 9	Crosswalk to 81321	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81321	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
76	20	NEW	Proprietary Laboratory Analyses:  GSP neuromuscular disorders / Genomic Sequencing Related Tests 	0236U	0236U	"SMN1 (survival of motor neuron 1, telomeric) and SMN2 (survival of motor neuron 2, centromeric) (eg, spinal muscular atrophy) full gene analysis, including small sequence changes in exonic and intronic regions, duplications and deletions, and mobile element insertions"	1. Crosswalk to 81329 + 81337: 9	Crosswalk to 81336+81405	CMS disagrees with the recommended crosswalk and instead recommends a crosswalk that represents both genes sequenced in this code. 	Crosswalk to 81336+81405	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends an alternate crosswalk.  CMS believes the methods are similar between the two codes. 		
77	21	NEW	Proprietary Laboratory Analyses:  GSP cardiovascular disorders / Genomic Sequencing Related Tests 	0237U	0237U	"Cardiac ion channelopathies (eg, Brugada syndrome, long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia), genomic sequence analysis panel including ANK2, CASQ2, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNQ1, RYR2, and SCN5A, including small sequence changes in exonic and intronic regions, deletions, duplications, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81413 + 81414: 9 	Crosswalk to 81413	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81413	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
78	22	NEW	Proprietary Laboratory Analyses:  GSP  Oncology / Genomic Sequencing Related Tests 	0238U	0238U	"Oncology (Lynch syndrome), genomic DNA sequence analysis of MLH1, MSH2, MSH6, PMS2, and EPCAM, including small sequence changes in exonic and intronic regions, deletions, duplications, mobile element insertions, and variants in non-uniquely mappable regions"	1. Crosswalk to 81435 + 81436: 9	Crosswalk to 81435	CMS agrees with part of the recommended crosswalk.  CMS considers the 'full gene sequence' to include all  components described in new code 	Crosswalk to 81435	Finalize as proposed. CMS continues to agree with part of the CDLT Panel recommendation to crosswalk recommended by the CDLT Panel.  CMS considers the 'full gene sequence' to include all  components described in new code 		
80	76	NEW	Proprietary Laboratory Analyses: GSP constitutional or other heritable disorders or syndromes / Genomic Sequencing Related tests	0X62U	0265U	"Rare constitutional and other heritable disorders, whole- genome and mitochondrial DNA sequence analysis, blood, frozen and formalin-fixed paraffin-embedded (FFPE) tissue, saliva, buccal swabs or cell lines, identification of single nucleotide and copy number variants"	"1. Crosswalk to 81425+81460: 5
2. Gapfill: 4"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
81	34	NEW	Proprietary Laboratory Analyses: GSP Oncology solid organ / Genomic Sequencing Related Tests 	0250U	0250U	"Oncology (solid organ neoplasm), targeted genomic sequence DNA analysis of 505 genes, interrogation for somatic alterations (SNVs [single nucleotide variant], small insertions and deletions, one amplification, and four translocations), microsatellite instability and tumor-mutation burden"	1. Crosswalk to 81455: 11	Crosswalk to 81455	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 81455	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
82	77	NEW	Proprietary Laboratory Analyses: GSP constitutional or other heritable disorders or syndromes / Genomic Sequencing Related tests	0X63U	0266U	"Unexplained constitutional or other heritable disorders or syndromes, tissue-specific gene expression by whole-transcriptome and next-generation sequencing, blood, formalin-fixed paraffin-embedded (FFPE) tissue or fresh frozen tissue, reported as presence or absence of splicing or expression changes"	"1. Crosswalk to 81425: 1
2. Crosswalk to 81415: 6
3. Gapfill: 1"	Gapfill	CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).	Gapfill	Finalize as proposed. CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
83	78	NEW	Proprietary Laboratory Analyses: GSP constitutional or other heritable disorders or syndromes / Genomic Sequencing Related tests	0X64U	0267U	"Rare constitutional and other heritable disorders, identification of copy number variations, inversions, insertions, translocations, and other structural variants by optical genome mapping and whole-genome sequencing"	"1. Crosswalk to 81425 + 81229: 7
2. Gapfill: 1"	Gapfill	"CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  In particular, gapfilling this code will help to understand the resources involved in optical genome mapping, which does not have a crosswalk on the CLFS. "	Gapfill	Finalize as proposed. CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
84	86	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X73U	0268U	"Hematology (atypical hemolytic uremic syndrome [aHUS]), genomic sequence analysis of 15 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81432: 5
2. Crosswalk to 81443: 5"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
85	87	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X74U	0269U	"Hematology (autosomal dominant congenital thrombocytopenia), genomic sequence analysis of 14 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81432 + 81433: 2
2. Crosswalk to 81443: 8"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
86	88	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X75U	0270U	"Hematology (congenital coagulation disorders), genomic sequence analysis of 20 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81432: 2
2. Crosswalk to 81443: 8"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
87	89	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X76U	0272U	"Hematology (genetic bleeding disorders), genomic sequence analysis of 51 genes, blood, buccal swab, or amniotic fluid, comprehensive"	1. Crosswalk to 81430: 10	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
88	91	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X78U	0274U	"Hematology (genetic platelet disorders), genomic sequence analysis of 43 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81443: 2
2. Crosswalk to 81430: 7"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
89	92	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X79U	0271U	"Hematology (congenital neutropenia), genomic sequence analysis of 23 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81443: 8
2. Gapfill: 1"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
90	93	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X80U	0273U	"Hematology (genetic hyperfibrinolysis, delayed bleeding), genomic sequence analysis of 8 genes (F13A1, F13B, FGA, FGB, FGG, SERPINA1, SERPINE1, SERPINF2, PLAU) blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81443: 4
2. Crosswalk to 81432: 6"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
91	94	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X81U	0276U	"Hematology (inherited thrombocytopenia), genomic sequence analysis of 23 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81443: 9
2.Gapfill: 1"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
92	95	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X82U	0277U	"Hematology (genetic platelet function disorder), genomic sequence analysis of 31 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81443: 3
2. Crosswalk to 81430: 7"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS continues to disagree with the  recommendation of the CDLT Panel and recommends to  gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
93	96	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X83U	0278U	"Hematology (genetic thrombosis), genomic sequence analysis of 12 genes, blood, buccal swab, or amniotic fluid"	"1. Crosswalk to 81443: 9
2. Gapfill: 1"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to better identify potential crosswalks for the genetic material being analyzed.  	Gapfill	Finalize as proposed.  CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
94	97	NEW	Proprietary Laboratory Analyses: GSP hematology / Genomic Sequencing Related Tests	0X84U	0282U	"Red blood cell antigen typing, DNA, genotyping of 12 blood group system genes to predict 44 red blood cell antigen phenotypes"	1. Crosswalk to 0001U: 10	Crosswalk to 0001U	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 0001U	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
95	75	NEW	Proprietary Laboratory Analyses:  Molecular Pathology (Other than GSP / Other Genomic Sequencing Related Tests 	0X61U	0264U	"Rare diseases (constitutional/heritable disorders), identification of copy number variations, inversions, insertions, translocations, and other structural variants by optical genome mapping"	"1. Crosswalk to 81229: 9
2. Gapfill: 1
3. Abstain: 1"	Gapfill	"CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  In particular, gapfilling this code will help to understand the resources involved in optical genome mapping, which does not have a crosswalk on the CLFS. "	Gapfill	Finalize as proposed. CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
96	27	NEW	Proprietary Laboratory Analyses: GSP Oncology solid organ / Other Genomic Sequencing Related Tests 	0244U	0244U	"Oncology (solid organ), DNA, comprehensive genomic profiling, 257 genes, interrogation for single-nucleotide variants, insertions/deletions, copy number alterations, gene rearrangements, tumor-mutational burden and microsatellite instability, utilizing formalin-fixed paraffin-embedded tumor tissue"	"1. Crosswalk to 0037U: 8
2. Gapfill: 1"	Gapfill	"CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  In particular, gapfilling this code will help to understand the resources involved in optical genome mapping, which does not have a crosswalk on the CLFS. "	Crosswalk to 0037U	"After additional review and further consideration, CMS agrees with the majority recommendation of the CDLT Panel to crosswalk this code.  The crosswalked code(s) appear to use similar methods and resource utilization."		
97	29	NEW	Proprietary Laboratory Analyses: GSP RBC antigens / Other Genomic Sequencing Related Tests 	0246U	0246U	"Red blood cell antigen typing, DNA, genotyping of at least 16 blood groups with phenotype prediction of at least 51 red blood cell antigens"	1. Crosswalk to 0001U: 10	Crosswalk to 0001U	CMS agrees with the majority  CDLT Panel recommendation to crosswalk the code.  Both codes appear to use similar methods and resource utilization.	Crosswalk to 0001U	Finalize as proposed. CMS agrees with the majority CDLT Panel recommendation to crosswalk the code.  The crosswalked code(s) appear to use similar methods and resource utilization.		
98	85	NEW	Proprietary Laboratory Analyses:  Molecular Pathology (Other than GSP / Other Genomic Sequencing Related Tests 	0X72U	0260U	"Rare diseases (constitutional/heritable disorders), identification of copy number variations, inversions, insertions, translocations, and other structural variants by optical genome mapping"	"1. Crosswalk to 81229: 9
2. Gapfill: 1
3. Abstain: 1"	Gapfill	"CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  In particular, gapfilling this code will help to understand the resources involved in optical genome mapping, which does not have a crosswalk on the CLFS. "	Gapfill	Finalize as proposed. CMS agrees with the minority recommendation of the CDLT Panel to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).		
99	99	NEW	Molecular Pathology chromosomal abnormalities / Other Genomic Sequencing Related Tests	812X0	81349	"Cytogenomic (genome-wide) analysis for constitutional chromosomal abnormalities; interrogation of genomic regions for copy number and loss-of-heterozygosity variants, low-pass sequencing analysis"	"1. Crosswalk to 81277: 4
2. Crosswalk to 81229: 6"	Gapfill	CMS disagrees with the recommendations to crosswalk this code and instead recommends to gapfill this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC).  CMS welcomes comments that would help to understand the difference in resources for low-pass sequencing analysis versus the methods used by the codes for proposed crosswalks.  	Gapfill	"After reviewing public comments, CMS continues to believe gapfilling this code so that the resources used in this code can be better estimated by a Medicare Administrative Contractor (MAC)"		
